Reframing treatment for ductal carcinoma in situ: could less be more?
نویسندگان
چکیده
In a typical breast surgery practice, nearly one-fifth of new patients present with ductal carcinoma in situ (DCIS), usually detected on mammography as an incidental finding. Most of these women are otherwise healthy, take care of themselves, have had a mammogram as part of their routine health maintenance, and are now grappling with a “cancer” diagnosis. When explaining to patients that DCIS generally has a favorable outcome and that it rarely affects mortality, it always becomes apparent that medical and surgical professionals still have more questions than answers regarding this disease. Is DCIS cancer or not? What would happen if no treatment for DCIS were available —if patients had to wait until they developed invasive cancer before choosing to have surgery? And how do we have a conversation with patients so that we can reduce the anxiety that often motivates these women to choose a bilateral mastectomy for a noninvasive disease?
منابع مشابه
Immunohistochemical Evaluation of Human p53 Tumor Suppressor Protein Content in Ductal Carcinoma in Situ of the Breast
The focus of this study was to determine if early detection of mutant p53 accumulation may be an early indicator of tumor aggressiveness and transformation to invasive breast cancer. For this purpose, the p53 content of 100 human breast biopsies classified as ductal carcinoma (DCIS), was evaluated by immunohistochemical method. All specimens were microscopically classified into histologic types...
متن کاملAndrogen Receptor Analysis in Relation to Estrogen and Progesterone Receptors as well as Histological Grade for Ductal Carcinoma In Situ of the Breast
Background and Objective: Since the advent of mammography screening, ductal carcinoma in situ (DCIS) of the breast has been diagnosed increasingly. In contrast to the situation in invasive breast carcinoma, there are only a few reports on androgen receptor (AR) status in DCIS and few reports on estrogen ...
متن کاملA Study of Matrix Metalloproteinase 9 and CD31 Expression through Immunohistochemistry in Invasive Breast Cancer
Background & Aims: This study was performed to investigate possible relationships between the manifestation of stromal cells (fibroblasts and/or myofibroblasts) by focusing on expression of their matrix metalloproteinase 9 (MMP9) and possible angiogenesis based on CD31 and CD34 antigen expression during the various steps of hyperplastic changes to precancerousstate and invasive breast cancer. M...
متن کاملMedullary Breast Carcinoma and Invasive Ductal Carcinoma: A Review Study
Background: Medullary breast carcinoma (MBC) is a unique histological subtype of breast cancer. The present study aimed to evaluate the classic and non-classic characteristics of MBC and its differences with IDC. The present review study incorporates 22 years of practical experience from a breast disease research center-based series of cases.Methods: Retrospectively, the medical records of 3,24...
متن کاملInsitu paget disease of breast: A case report
Introduction: Mammary Paget’s disease is generally accompanied by in situ ductal carcinoma, consequently, prompt diagnosis and treatment can halt further invasion and yield better prognosis. Case Presentation: The patient was a 39-year old woman, who presented with superficial ulcers and nipple discharge of left breast, She had no palpable mass underneath. The patient was G2 P2 and under oral ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Bulletin of the American College of Surgeons
دوره 97 6 شماره
صفحات -
تاریخ انتشار 2012